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Seracult and Seracult Plus Fecal Occult Blood Test Guide

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FOBT Testing Information Colorectal Cancer Screening Guidelines Customer FAQ


FOBT Testing Information

Yearly screening with Seracult FOBT is a simple, reliable and non-invasive method for the early detection of diseases of the colon and rectum. Seracult has a proven track record aiding with early diagnosis and better patient outcomes. For more information about Propper's Seracult Fecal Occult Blood Tests please click the image below to be taken to the product pages.

Seracult FOBT Testing Products

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Colorectal Cancer Screening Resources

Summary of Risk Factors for Colorectal Cancer

Life-Style Related Risk Factors

  • A diet high in red meat and/or processed meats
  • Physical inactivity
  • Obesity
  • Smoking
  • Heavy alcohol consumption

Non-Life Style Related Risk Factors

  • Age - risk increases at around 50 years of age
  • Individual - history of adenomatous polyps or colorectal cancer
  • Individual - history of Inflamatory Bowel Disease, ulcerative colitis and/or Crohn's disease
  • Family - relatives with a history of colorectal cancer or adenomatous polyps
  • Heredity - genetic conditions such as: Familial adenomatous polyposis (FAP), Hereditary non-polyposis colon cancer (HNPCC or Lynch syndrome), Turcot syndrome, Peutz-Jeghers syndrome, MUTYH-associated polyposis
  • Racial/Ethnic Background - African Americans are at increased risk (US only) and Jews of Eastern European descent are at increased risk (globally)
  • Type 2 Diabetes

SOURCE: American Cancer Society Colorectal Cancer Risk Guidelines

Screening Recommendations Summary

High-Sensitivity fecal occult blood test (FOBT)

  • Every year over age 50 for normal risk patients
  • Screening should begin earlier if patient is at increased risk based on a physician's assessment

Flexible Sigmoidoscope

  • Every 5 years starting at age 50


  • Every 10 years starting at age 50

SOURCE: Centers for Disease Control Colorectal Cancer Screening Guidelines

Healthcare Provider Cancer Screening Resources

American Cancer Society Physician's Action Plan

How to Increase Colorectal Cancer Screening Rates in Practice: A Primary Care Clinician’s Evidence-Based Toolbox and Guide (PDF)


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Customer FAQ

Q: What is the sensitivity level of Seracult?  
A: Sensitivity for Seracult is 0.38 mg of hemoglobin per 100ml of water.  

Q: What is the sensitivity level of Seracult Plus?  
A: Sensitivity for Seracult Plus is 0.32 mg of hemoglobin per 100 ml of water.  

Q: What is the difference between Seracult and Seracult Plus?
A: Seracult Plus is a more sensitive test than Seracult and is intended for patients deemed at an increased risk of colorectal cancer.

Q: Who should be tested for Colorectal Cancer?  
A: The American Cancer Society recommends annual testing for Colorectal Cancer for persons 50 years of age and over. Clinicians may also use this test for occult blood due to other gastrointestinal bleeding.

Q: Who should be tested with Seracult Plus?  
A: Any person that has higher risk factors due to medical or family history.  

Q: Is Seracult and Seracult Plus CLIA waved?  
A: Yes, both tests are CLIA waved.

Q: What CPT codes can be used?  

  • Screening CPT: 82270 Blood, occult, by peroxidase activity (eg, guaiac), qualitative; feces, consecutive collected specimens with single determination, for colorectal neoplasm screening [ie, patient was provided 3 cards or single triple card for consecutive collection]
  • Diagnostic CPT: 82272 Blood, occult, by peroxidase activity (eg, guaiac), qualitative, feces, 1-3 simultaneous determinations, performed for other than colorectal neoplasm screening.

Q: How long can the sample remain on the collection card before test development?  
A: The sample is stable for 28 days under normal conditions.  

Q: Can different lot numbers of developer and slides be used together?  
A: Yes, as long as the expiration dates are valid and you are not combining Seracult and Seracult Plus products.  

Q: Is the collection tissue septic safe?  
A: Yes, the collection tissue is septic safe.  

Q: To which address do I send the test when all samples have been applied?  
A: The test should be mailed or brought back to the doctor's office, screening program or hospital where you obtained the test. Propper does not process test samples.

Q: What storage conditions are required for the developer?  
A: The developer should be stored in a dark place, kept away from heat and light.

Q: How is a positive result interpreted?  
A: Any indication of a blue color in the test area, assuming you have a positive blue color in the control line. If using a triple slide, a blue color in any of the test areas is a positive result.  

Q: If the patient applies the sample to the reverse side of the slide, is the test still valid?
A: No, the patient must be retested.   

Q: Does Seracult or Seracult Plus contain latex or DEHP?  
A: No, our Seracult products are both latex-free & DEHP free.

Q: Does Propper consult patients on test results?  
A: No. Propper's scientists cannot consult patients due to HIPAA regulations.  

Q: Are there any advantages of guaiac FOBT testing over immunoassay FOBT (iFOBT or FIT) tests?  

  • Guaiac testing has been in practice for over 3 decades and has many clinical trials to substantiate its claims.  
  • Most iFOBT tests use buffers to dissolve samples. Typically, after adding the sample to the buffer, a reaction starts and sensitivity gradually decreases, especially at room temperature.  
  • Delivery delays & temperature fluctuations can result in false negatives. 
  • iFOBT  is less sensitive to bleeding in the upper GI tract. 

Q: Any advantages of using Seracult and Seracult Plus over competitors?

  • Seracult and Seracult Plus has a more visible and intense blue color as a positive indicator.
  • Seracult has a patented enhanced formula for higher sensitivity. Only one other competitor (Beckman-Coulter) also has a higher sensitivity test.
  • Seracult and Seracult Plus samples are mailed in a USPS approved envelope.

Q: Do healthy people lose blood from the gastrointestinal tract?  
A: Yes, the average normal blood loss ranges from .5 ml to 1.5 ml per day. Seracult and Seracult Plus sensitivities are above that cut off level minimizing false positives. 

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